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Increased survival rate and decreased tumor growth in IL-1β KO mice. (A) Survival after i.v. injection of B16 melanoma into IL-1β KO (n = 10) compared with WT mice (n = 10). (B) Frequency of lung micrometastases as detected in histological sections on day 14 after tumor cell injection (n = 10). (C) Tumor size of B16 melanoma after i.f.p. injection (2 × 105 cells per mouse; n = 5 per group). Results shown are from one experiment of six performed.
