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. 1999 Jan 19;96(2):355–360. doi: 10.1073/pnas.96.2.355

Figure 2.

Figure 2

Structure of hGH-GLp65 and hGH-H-GLp65. The constructs contain the left terminus of adenovirus type 5 (nucleotides 1–440), a 16,054-bp fragment of the human hypoxanthine-guanine phophoribosyltransferase gene, a regulatory cassette containing the regulator GLp65. UAS-TATA-GH, hGH under upstream activation sequence–TATA control; 2 × HS4, insulator, a 5′element of the chicken β-globin domain (from G. Felsenfeld); TTRB, liver-specific promoter enhancer (from R. Costa); GLp65, inducible gene switch p65 activation domain; SV40, poly(A), the 6,545-bp fragment out of the C346 cosmid and the right terminus of adenovirus type 5 (nucleotides 35,818–35,935). HGH-H-GLp65 contains an insulator sequence; hGH-GLp65 does not.