Table 5.

Incidence of CNV spots when 50 μg of Icon protein was administered by i.v. injection 1 day after laser treatment

Treatment	No. of mice	Laser spots per eye	Total spots	CNV- positive spots	CNV- negative spots
Human IgG1	3	3	18	16 (89%)	2 (11%)
Icon protein	3	3	18	2 (11%)	16 (89%)

Laser spots were produced in C57BL/6 mice on day 0, and an i.v. injection of 50 μg of a human IgG1 control or Icon protein was administered on day 1. The mice were killed on day 7. A Chi-square test of the data showed P < 0.0001.