Table 1.
Distribution and functional classification of genes belonging to the ToxR regulon
| toxR | tcpPH | toxT | |
|---|---|---|---|
| Total no. of genes identified | 154 | 58 | 18 |
| Total no. of genes induced | 60 | 27 | 13 |
| Total no. of genes repressed | 94 | 31 | 5 |
| Chromosome location | |||
| Large chromosome | 102 (66.2) | 39 (67.2) | 14 (77.8) |
| Small chromosome | 52 (33.8) | 19 (32.8) | 4 (22.2) |
| Functional class | |||
| Adaptation to atypical conditions | 1 (0.6) | 1 (1.7) | 0 |
| Amino acid biosynthesis | 4 (2.6) | 0 | 0 |
| Chemotaxis and motility | 6 (3.9) | 1 (1.7) | 0 |
| Cofactor | 1 (0.6) | 0 | 0 |
| Conserved, conserved hypothetical, and unknown | 33 (20.4) | 10 (17.2) | 2 (11.1) |
| Energy metabolism | 31 (20.1) | 12 (20.7) | 1 (5.6) |
| Pathogenicity | 22 (14.3) | 19 (32.8) | 11 (61.1) |
| Protein synthesis | 7 (4.5) | 0 | 0 |
| Purines, pyrimidines, nucleosides, and nucleotides | 6 (3.9) | 1 (1.7) | 1 (5.6) |
| Regulatory | 8 (5.2) | 4 (6.9) | 0 |
| Transport and cell envelope | 35 (22.7) | 10 (17.2) | 3 (16.7) |
No. of genes (% of total genes identified) showing a ≥2-fold change in expression in the indicated strain. All strains were grown under AKI conditions to promote expression of virulence genes.