Figure 3.
Time course of SW1116 tumor growth inhibition by the recombinant vaccinia virus carrying MBP genes. Four different groups of SW1116 tumor-bearing KSN nude mice were inoculated intratumorally (A) or subcutaneously (B) with three consecutive doses of 5 × 106 pfu of WT-RVV, G54D-RVV, WR-VV control, or saline control (arrows). Tumor size was measured in three dimensions every 3–4 days with Vernier calipers. Differences in tumor size were statistically analyzed with the Kruskal–Wallis test and the Wilcoxon test.