Table 1.
Chromosomal positions of retinoid cascase genes and AD linkages or associations
| Retinoid locus
|
Alzheimer's disease locus
|
|||||
|---|---|---|---|---|---|---|
| Band/Gene | kb | Band/Gene or Marker | kb | cM | LOD/significance | Ref. |
| 12q13 | 12q13 | |||||
| RARG | 53,518–53,528 | D12S345–D12S78 | 32,352–104,143 | 55.25–111.87 | LOD 6.374 | 109 |
| RDH5 | 56,187–56,192 | D12S96 | 53,147 | 67.16 | P < 0.001 | 18 |
| RODH | 57,370–57,405 | D12S390 | 52,901 | 67.17 | LOD 2.3 | 19 |
| D12S1632 | 56,979 | 71.7 | LOD 2.43 APOE4− | 110 | ||
| LRP1 | 57,747–57,764 | – | O.R. 1.8; P < 0.01 | 24 | ||
| No association | 23 | |||||
| 10q23 | 10q23 | |||||
| CYP26A1 | 94,067–94,071 | IDE | 93,434–93,555 | – | P = 0.04 | 20 |
| Disequilibrium/No linkage | 22 | |||||
| RBP4 | 94,585–94,595 | D10S583 | 93,590 | 115.27 | Z max 2.8 | 20 |
| CYP2C9 | 95,932–95,982 | P = 0.008 | 111 | |||
| CYP2C8 | 96,030–96,062 | D10S1239 | 102,430 | 121.81 | LOD 2.62 | 112 |
| 2p12 | 2p13 | |||||
| CYP26A2/P450RAI-2 | 72,567–72,586 | D2S1356 | 43,542 | 64.29 | MLS 3.52 | 25 |
| 17q12-q21 | 17q12-q21 | |||||
| RARA | 40,640–40,688 | D17S1787 | 41,835 | 70.08 | MLOD 5.51 | 27 |
| 1q21.3-q23 | 1q21.3-q23 | |||||
| CRABP2 | 152,434–152,441 | D1S1595–D1S2844 | 151,436–160,583 | 148.85–160.43 | No mutations or SNPs | 31 |
| RXRG | 161,021–161,065 | 170 | MLS 2.67 | 28 | ||
| D1S518 | 182,978 | 188.02 | P <0.03 | 29 | ||
| 6p21.3 | 6p21.3 | |||||
| RXRB | 33,158–33,165 | TNFA | 31,597–31,600 | 51.31 | NPL 2.3 | 32 |
| P < 0.03 APOE+ | 33 | |||||
| D6S1019 | 38,975 | – | LOD 1.3 | 19 | ||
| 3q23 | 3q23 | |||||
| RBP2 | 140,000–140,028 | D3S3554–D3S1569 | 140,435–144,219 | 146.07–150.58 | MLOD 4.17 plaque only | 34 |
| RBP1 | 140,065–140,088 | |||||
| 9q34.3 | 9q34.2 | |||||
| RXRA | 129,062–129,102 | MLS 1.96 | 113 | |||
Chromosomal positions as band, kilobase (kb), centiMorgan (cM) for selected genes of the retinoid cascade and genes or markers linked to AD at those loci. Markers and genes were located using the Locus Link database (http://www.ncbi.nlm.nih.gov/LocusLink/) posted as of January 22, 2003. Where available, the DeCode position was reported.