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. 2003 Feb 14;100(5):2911–2916. doi: 10.1073/pnas.0536856100

Figure 1.

Figure 1

DR delays the onset of motor dysfunction, reduces weight loss, and increases the survival of HD N171-82 Q mice. (a) Eight-week-old male HD mice were maintained on an alternative day fasting regimen (DR) or an AL feeding regimen for 3 mo. Onset of disease was scored as the first date when limb tremors were detected. Values are the mean and SE (n = 12 mice per group); *, P < 0.001 (paired t test). (b) Survival plots for HD mice maintained on AL or DR diets. (c) Body weights for HD mice maintained on AL or DR diets. Values are the mean and SE (12 mice per group). (d and e) Motor behavioral performance was evaluated by using a rotarod apparatus in 16- and 20-wk-old nontransgenic (Non-Tg) and HD mice maintained on AL or DR diets. The number of times the mouse fell from the rod (d) and the total time spent on the rod (e) during a 5-min period were recorded. Values are the mean and SE (n = 6–15 mice per group). *, P < 0.01, compared with the non-Tg AL value; **, P < 0.01 compared with the HD AL value (ANOVA with Scheffé post hoc tests).