Figure 2.

Deduced protein sequence of MIHCK. The C-terminal catalytic domain and the p21-binding region near the N terminus are boxed; the CRIB motif is underlined; acidic residues are in red, basic in green, and prolines in blue. Residues 451–753 are identical to the sequence of the previously cloned catalytic domain (13) and sequences 102–117, 198–212, 255–262, 285–299, 314–328, 437–462, and 626–640 correspond to the N-terminal sequences of seven proteolytic fragments of native kinase (11, 12).