Figure 3.

Schematic representation of the MIHCK molecule. The numbers correspond to the residue numbers in full-length kinase. The regions of interest discussed in the text are indicated at the top of the figure. In addition to the essential autophosphorylation site (P) shown in the catalytic domain, there are multiple other autophosphorylation sites (P), especially in the central, basic, Pro-rich region (ref. 12; and see text) and possibly in the N-terminal region (?). The origins of the proteolytic fragments described previously (11, 12), and whose properties are discussed in the text, are shown at the bottom of the figure.