Figure 6.

Sensitivity of AKT3-WT and Mutant Channels towards Monovalent Cations.

Relative steady state outward K⁺ currents (I_ss) at +40 mV in response to a replacement of 100 mM external K⁺ by Rb⁺, Cs⁺, Li⁺, or Na⁺. Currents were normalized to I_ss in 100 mM external K⁺ concentration (dotted line). Results represent means ± sd of three or more experiments. Note that in AKT3-WT and H228D, neither Li⁺ nor Na⁺ can substitute for K⁺, whereas mutants carrying a mutation at Ser-271 mediate outward currents irrespective of the nature of the cation present in the bath.