TABLE 1.
Quorum-activated genes
| Gene no.a | Descriptionb | Maximum changec
|
||
|---|---|---|---|---|
|
lasI rhlI mutant
|
Wild type vs lasR rhlR mutant | |||
| 3OC12-HSL | C4-HSL + 3OC12-HSL | |||
| PA0007 | Hypothetical protein | 4.4 | 5.7 (2.0) | 14 (1.4) |
| PA0026 | Hypothetical proteind | 4.4 | 4.4 (1.4) | 5.9 (0.2) |
| PA0027 | Hypothetical protein | 3.8 | 4.9 (0.8) | 5.7 (0.2) |
| PA0028 | Hypothetical protein | 5.8 | 7.5 (1.4) | 8.2 (1.4) |
| PA0050 | Hypothetical protein | 2.8 | 2.5 (2.0) | 3.0 (1.4) |
| PA0052 | Hypothetical proteind | 4.7 | 8.3 (1.4) | 22 (2.0) |
| PA0059 | osmC, osmotically inducible protein OsmC | 2.5 | 6.7 (2.0) | 8.9 (2.0) |
| PA0105 | coxB, cytochrome c oxidase subunit II | 3.4 | 4.0 (2.0) | 2.6 (2.0) |
| PA0106 | coxA, cytochrome c oxidase subunit I | 4.2 | 4.8 (1.4) | 3.3 (1.4) |
| PA0107 | Conserved hypothetical protein | 4.1 | 4.8 (2.0) | 4.9 (2.0) |
| PA0108 | coIII, cytochrome c oxidase subunit III | 3.0 | 3.6 (2.0) | 2.8 (2.0) |
| PA0109 | qsc115, hypothetical protein | 2.1 | 3.5 (1.4) | 4.1 (1.4) |
| PA0122 | Conserved hypothetical proteine | 13 | 36 (1.4) | 51 (1.4) |
| PA0132 | Beta-alanine-pyruvate transaminase | 1.6 | 3.1 (1.4) | 4.1 (2.0) |
| PA0143 | Probable nucleoside hydrolase | 4.7 | 4.7 (0.4) | 5.4 (0.1) |
| PA0144 | Hypothetical protein | 1.5 | 19 (2.0) | 28 (2.0) |
| PA0158 | Probable RND efflux transporter | 2.6 | 2.6 (2.0) | 2.6 (2.0) |
| PA0175 | Probable chemotaxis protein methyltransferase | 2.0 | 2.6 (3.0) | 4.6 (1.4) |
| PA0176 | Probable chemotaxis transducer | 2.1 | 2.6 (3.0) | 3.9 (1.4) |
| PA0179 | Probable two-component response regulator | 2.7 | 2.8 (1.4) | 3.7 (1.4) |
| PA0198 | exbBI, transport protein ExbB | 7.3 | 10 (4.0) | 3.7 (4.0) |
| PA0263 | hcpC, secreted protein Hcp | 1.7 | 8.9 (1.4) | 9.4 (1.4) |
| PA0355 | pfpI, protease PfpI | 2.3 | 4.8 (2.0) | 8.1 (2.0) |
| PA0364 | Probable oxidoreductase | 2.9 | 3.1 (2.0) | 3.0 (2.0) |
| PA0365 | Hypothetical protein | 2.0 | 2.5 (2.0) | 2.7 (2.0) |
| PA0366 | Probable aldehyde dehydrogenase | 2.4 | 2.8 (2.0) | 2.5 (3.0) |
| PA0534 | Conserved hypothetical protein | 1.5 | 2.9 (4.0) | 9.8 (2.0) |
| PA0567 | Conserved hypothetical protein | 6.9 | 15 (2.0) | 11 (2.0) |
| PA0572 | Hypothetical protein | 19 | 22 (0.4) | 19 (0.05) |
| PA0586 | Conserved hypothetical protein | 2.1 | 2.6 (1.4) | 4.6 (1.4) |
| PA0852 | qsc129, cpbD, chitin-binding protein CbpD precursord | 11 | 43 (0.4) | 94 (0.1) |
| PA0855 | qsc116, hypothetical protein | 2.4 | 2.5 (0.8) | 3.0 (0.8) |
| PA0996 | Probable coenzyme A ligasee | 220 | 90 (0.8) | 42 (0.2) |
| PA0997 | Hypothetical protein | 110 | 96 (0.8) | 200 (0.05) |
| PA0998 | Hypothetical protein | 68 | 40 (0.4) | 200 (0.2) |
| PA0999 | fabHI, 3-oxoacyl-(acyl carrier protein) synthase III | 37 | 25 (0.8) | 45 (0.2) |
| PA1000 | Hypothetical protein | 22 | 12 (0.8) | 44 (0.2) |
| PA1001 | phnA, anthranilate synthase component I | 39 | 23 (0.8) | 290 (0.2) |
| PA1002 | phnB, anthranilate synthase component II | 17 | 13 (1.4) | 28 (0.8) |
| PA1003 | Probable transcriptional regulator | 8.1 | 6.6 (0.2) | 78 (0.05) |
| PA1130 | Hypothetical protein | 2.4 | 9.4 (1.4) | 16 (1.4) |
| PA1131 | Probable MFS transporterd | 1.7 | 5.0 (2.0) | 7.9 (1.4) |
| PA1173 | napB, cytochrome c-type protein NapB precursor | 2.3 | 2.8 (2.0) | 4.1 (1.4) |
| PA1175 | napD, NapD protein of periplasmic nitrate reductase | 2.6 | 2.4 (2.0) | 3.8 (1.4) |
| PA1176 | napF, ferredoxin protein NapF | 2.5 | 2.5 (2.0) | 5.8 (1.4) |
| PA1177 | napE, periplasmic nitrate reductase protein NapE | 2.9 | 3.6 (1.4) | 3.6 (1.4) |
| PA1215 | Hypothetical protein | NC | 18 (1.4) | 55 (1.4) |
| PA1216 | Hypothetical protein | 4.7 | 15 (0.8) | 120 (0.8) |
| PA1217 | Probable 2-isopropylmalate synthase | 2.9 | 41 (1.4) | 380 (1.4) |
| PA1218 | Hypothetical protein | NC | 6.9 (1.4) | 160 (1.4) |
| PA1221 | Hypothetical proteine | NC | 3.1 (3.0) | 11 (1.4) |
| PA1245 | Hypothetical proteine | 8.6 | 10 (0.8) | 11 (0.2) |
| PA1246 | aprD, alkaline protease secretion protein AprD | 8.6 | 9.8 (1.4) | 6.6 (0.8) |
| PA1247 | aprE, alkaline protease secretion protein AprE | 6.2 | 6.4 (1.4) | 9.1 (1.4) |
| PA1248 | aprF, alkaline protease secretion protein AprF | 7.2 | 7.6 (1.4) | 5.2 (1.4) |
| PA1249 | aprA, alkaline metalloproteinase precursor | 25 | 27 (1.4) | 22 (1.4) |
| PA1250 | aprI, alkaline proteinase inhibitor AprId | 20 | 20 (0.2) | 24 (0.05) |
| PA1289 | Hypothetical protein | 2.9 | 5.7 (1.4) | 2.6 (1.4) |
| PA1317 | cyoA, cytochrome o ubiquinol oxidase subunit II | 2.5 | 4.7 (4.0) | 15 (2.0) |
| PA1318 | cyoB, cytochrome o ubiquinol oxidase subunit I | NC | 3.9 (4.0) | 16 (2.0) |
| PA1319 | cyoC, cytochrome o ubiquinol oxidase subunit III | 2.0 | 4.8 (4.0) | 7.9 (3.0) |
| PA1320 | cyoD, cytochrome o ubiquinol oxidase subunit IV | 42 | 71 (4.0) | 9.1 (3.0) |
| PA1323 | Hypothetical protein | 2.8 | 6.1 (2.0) | 9.6 (2.0) |
| PA1324 | Hypothetical protein | 2.4 | 5.3 (2.0) | 8.5 (2.0) |
| PA1404 | Hypothetical protein | 2.0 | 2.7 (2.0) | 3.8 (2.0) |
| PA1431 | rsaL, regulatory protein RsaLd | 350 | 340 (0.2) | 39 (0.8) |
| PA1432 | lasI, autoinducer synthesis protein LasId | NCf | NCf | 7.7 (0.8) |
| PA1656 | Hypothetical proteina | 2.4 | 3.7 (1.4) | 5.7 (0.8) |
| PA1657 | Conserved hypothetical protein | 5.9 | 15 (0.4) | 24 (0.8) |
| PA1658 | Conserved hypothetical protein | 3.9 | 9.3 (0.8) | 17 (0.8) |
| PA1659 | Hypothetical protein | 4.1 | 8.5 (0.8) | 17 (0.8) |
| PA1660 | Hypothetical protein | 2.6 | 7.9 (0.8) | 16 (0.8) |
| PA1661 | Hypothetical protein | 2.3 | 4.4 (1.4) | 4.4 (0.8) |
| PA1662 | Probable ClpA/B-type protease | 2.9 | 6.6 (1.4) | 7.7 (0.8) |
| PA1663 | Probable transcriptional regulator | 2.5 | 4.5 (0.8) | 9.1 (0.8) |
| PA1664 | Hypothetical protein | 5.9 | 16 (0.4) | 22 (0.8) |
| PA1665 | Hypothetical protein | 21 | 55 (1.4) | 28 (0.8) |
| PA1666 | Hypothetical protein | 2.9 | 12 (0.8) | 38 (0.8) |
| PA1667 | Hypothetical protein | 3.1 | 7.6 (0.8) | 12 (0.8) |
| PA1668 | Hypothetical protein | 2.8 | 4.6 (0.8) | 6.3 (0.8) |
| PA1669 | Hypothetical protein | 2.2 | 3.8 (1.4) | 17 (0.8) |
| PA1670 | stp1, serine/threonine phosphoprotein phosphatase Stp1 | NC | 2.8 (1.4) | 3.6 (0.8) |
| PA1745 | Hypothetical protein | 2.1 | 2.6 (2.0) | 2.8 (1.4) |
| PA1784 | Hypothetical proteine | 14 | 15 (1.4) | 18 (1.4) |
| PA1869 | qsc117, probable acyl carrier proteine | 7.8 | 41 (0.2) | 340 (0.2) |
| PA1870 | Hypothetical protein | NC | 3.2 (2.0) | 6.3 (2.0) |
| PA1871 | lasA, LasA protease precursord | 48 | 88 (0.8) | 130 (1.4) |
| PA1881 | Hypothetical protein | 2.4 | 2.6 (2.0) | 2.8 (1.4) |
| PA1888 | Hypothetical protein | 2.7 | 2.3 (2.0) | 4.3 (1.4) |
| PA1891 | Hypothetical protein | 3.3 | 4.3 (2.0) | 6.5 (0.8) |
| PA1893 | Hypothetical protein | 16 | 13 (0.4) | 2.7 (2.0) |
| PA1894 | qsc101, hypothetical protein | 59 | 59 (0.8) | 5.0 (1.4) |
| PA1895 | Hypothetical protein | 36 | 31 (0.8) | 4.2 (1.4) |
| PA1896 | Hypothetical protein | 41 | 49 (1.4) | 3.1 (1.4) |
| PA1897 | qsc102, hypothetical proteine | 130 | 130 (0.4) | 8.5 (0.8) |
| PA1914 | Conserved hypothetical protein | 42 | 190 (2.0) | 700 (2.0) |
| PA1921 | Hypothetical protein | NC | 14 (2.0) | 13 (2.0) |
| PA1930 | Probable chemotaxis transducer | 2.2 | 2.9 (2.0) | 3.8 (1.4) |
| PA1939 | Hypothetical protein | 2.6 | 3.2 (1.4) | 2.9 (2.0) |
| PA2030 | Hypothetical protein | 3.3 | 4.2 (2.0) | 14 (2.0) |
| PA2031 | Hypothetical protein | 4.5 | 6.5 (0.4) | 12 (1.4) |
| PA2066 | Hypothetical protein | 1.9 | 3.7 (2.0) | 12 (1.4) |
| PA2067 | Probable hydrolase | 1.8 | 5.0 (2.0) | 19 (1.4) |
| PA2068 | Probable MFS transporter | NC | 16 (1.4) | 150 (1.4) |
| PA2069 | Probable carbamoyl transferasee | NC | 45 (1.4) | 110 (0.2) |
| PA2076 | Probable transcriptional regulatord | 3.7 | 4.3 (0.2) | 4.3 (0.2) |
| PA2080 | Hypothetical protein | 3.5 | 4.0 (0.2) | 4.0 (0.2) |
| PA2081 | Hypothetical protein | 3.3 | 4.3 (0.2) | 3.6 (0.2) |
| PA2134 | Hypothetical protein | 3.1 | 5.4 (3.0) | 7.9 (2.0) |
| PA2142 | Probable short-chain dehydrogenase | NC | 3.6 (3.0) | 19 (2.0) |
| PA2143 | Hypothetical protein | 21 | 39 (2.0) | 51 (2.0) |
| PA2144 | glgP, glycogen phosphorylase | 2.5 | 4.7 (3.0) | 15 (2.0) |
| PA2146 | Conserved hypothetical protein | 2.7 | 4.8 (3.0) | 11 (2.0) |
| PA2147 | katE, catalase HPII | 3.5 | 7.1 (2.0) | 35 (2.0) |
| PA2148 | Conserved hypothetical protein | NC | 3.1 (2.0) | 3.4 (2.0) |
| PA2151 | Conserved hypothetical protein | 2.6 | 38 (2.0) | 34 (2.0) |
| PA2152 | Probable trehalose synthase | 2.1 | 5.3 (2.0) | 6.1 (2.0) |
| PA2153 | glgB, 1,4-alpha-glucan branching enzyme | 2.1 | 5.6 (2.0) | 16 (2.0) |
| PA2156 | Conserved hypothetical protein | 2.3 | 4.8 (3.0) | 17 (2.0) |
| PA2157 | Hypothetical protein | 2.1 | 2.8 (3.0) | 2.9 (3.0) |
| PA2158 | Probable alcohol dehydrogenase (Zn dependent) | 6.7 | 15 (2.0) | 26 (2.0) |
| PA2159 | Conserved hypothetical protein | 4.1 | 5.9 (2.0) | 10 (2.0) |
| PA2160 | Probable glycosyl hydrolased | 2.3 | 4.4 (3.0) | 5.8 (2.0) |
| PA2161 | Hypothetical proteind | 4.4 | 6.3 (2.0) | 10 (2.0) |
| PA2163 | Hypothetical protein | 2.2 | 6.9 (2.0) | 31 (2.0) |
| PA2164 | Probable glycosyl hydrolase | 2.5 | 4.7 (2.0) | 6.5 (2.0) |
| PA2165 | Probable glycogen synthase | 3.2 | 5.7 (2.0) | 6.3 (2.0) |
| PA2166 | Hypothetical protein | 3.1 | 9.1 (2.0) | 17 (2.0) |
| PA2167 | Hypothetical protein | 2.3 | 2.6 (2.0) | 4.7 (2.0) |
| PA2169 | Hypothetical protein | 2.8 | 5.7 (2.0) | 5.1 (2.0) |
| PA2170 | Hypothetical protein | 3.6 | 6.9 (2.0) | 13 (2.0) |
| PA2171 | Hypothetical protein | 5.2 | 9.1 (2.0) | 22 (2.0) |
| PA2172 | Hypothetical protein | 3.8 | 7.7 (2.0) | 12 (2.0) |
| PA2173 | Hypothetical protein | 3.5 | 6.5 (2.0) | 17 (2.0) |
| PA2176 | Hypothetical protein | 1.4 | 5.3 (2.0) | 27 (2.0) |
| PA2180 | Hypothetical protein | 1.9 | 2.6 (3.0) | 2.7 (3.0) |
| PA2190 | Conserved hypothetical protein | 3.4 | 4.5 (2.0) | 7.5 (2.0) |
| PA2192 | Conserved hypothetical protein | NC | 10 (2.0) | 8.4 (2.0) |
| PA2193 | hcnA, hydrogen cyanide synthase HcnAe | 140 | 190 (0.2) | 88 (0.2) |
| PA2194 | qsc128, hcnB, hydrogen cyanide synthase HcnB | 37 | 51 (0.2) | 59 (0.8) |
| PA2195 | hcnC, hydrogen cyanide synthase HcnC | 16 | 30 (0.4) | 46 (0.8) |
| PA2274 | Hypothetical protein | NC | 3.4 (3.0) | 11 (2.0) |
| PA2300 | chiC, chitinasee | 1.7 | 14 (1.4) | 100 (1.4) |
| PA2302 | qsc100, probable nonribosomal peptide synthetase | 5.2 | 7.9 (0.8) | 130 (1.4) |
| PA2303 | qsc107, hypothetical protein | 25 | 28 (0.4) | 130 (0.2) |
| PA2304 | Hypothetical protein | 8.4 | 12 (0.8) | 29 (0.8) |
| PA2305 | Probable nonribosomal peptide synthetase | 52 | 51 (0.2) | 70 (0.2) |
| PA2327 | Probable permease of ABC transporter | 5.9 | 8.9 (4.0) | 6.9 (4.0) |
| PA2328 | Hypothetical protein | 6.8 | 9.1 (2.0) | 7.5 (3.0) |
| PA2329 | Probable component of ABC transporter | 7.8 | 9.9 (1.4) | 18 (3.0) |
| PA2330 | Hypothetical protein | 7.9 | 11 (0.8) | 15 (2.0) |
| PA2331 | Hypothetical protein | 8.3 | 19 (1.4) | 20 (1.4) |
| PA2345 | Conserved hypothetical proteine | 2.2 | 3.2 (2.0) | 2.6 (2.0) |
| PA2365 | Conserved hypothetical protein | 4.7 | 5.4 (1.4) | 5.9 (1.4) |
| PA2366 | Conserved hypothetical protein | 4.3 | 5.2 (1.4) | 6.9 (1.4) |
| PA2367 | Hypothetical protein | 4.8 | 5.1 (1.4) | 6.4 (1.4) |
| PA2368 | Hypothetical protein | 3.5 | 3.4 (1.4) | 7.5 (1.4) |
| PA2370 | Hypothetical protein | 2.9 | 3.6 (3.0) | 3.5 (1.4) |
| PA2371 | Probable ClpA/B-type protease | 2.4 | 2.6 (3.0) | 5.0 (1.4) |
| PA2372 | Hypothetical protein | 3.2 | 2.7 (2.0) | 3.7 (1.4) |
| PA2414 | l-Sorbosone dehydrogenase | 3.1 | 4.9 (2.0) | 21 (0.2) |
| PA2415 | Hypothetical protein | 3.5 | 5.6 (2.0) | 14 (2.0) |
| PA2423 | Hypothetical protein | 11 | 11 (0.4) | 13 (0.2) |
| PA2433 | Hypothetical protein | 2.8 | 5.9 (2.0) | 11 (2.0) |
| PA2442 | gcvT2, glycine cleavage system protein T2 | 2.0 | 2.6 (3.0) | 3.1 (3.0) |
| PA2444 | glyA2, serine hydroxymethyltransferase | 9.1 | 12 (3.0) | 10 (3.0) |
| PA2445 | gcvP2, glycine cleavage system protein P2 | 6.6 | 7.5 (4.0) | 11 (3.0) |
| PA2446 | gcvH2, glycine cleavage system protein H2 | 12 | 17 (4.0) | 18 (3.0) |
| PA2448 | Hypothetical protein | NC | 4.1 (3.0) | 12 (1.4) |
| PA2512 | antA, anthranilate dioxygenase large subunit | −600 | 43 (2.0) | 27 (3.0) |
| PA2513 | antB, anthranilate dioxygenase small subunit | −96 | 14 (2.0) | 13 (3.0) |
| PA2514 | antC, anthranilate dioxygenase reductase | −67 | 9.3 (2.0) | 3.8 (4.0) |
| PA2564 | Hypothetical protein | 2.9 | 7.8 (2.0) | 21 (1.4) |
| PA2565 | Hypothetical protein | 3.1 | 6.6 (2.0) | 14 (2.0) |
| PA2566 | Conserved hypothetical proteine | 6.5 | 13 (2.0) | 21 (1.4) |
| PA2570 | pa1L, PA-1 galactophilic lectind | NC | 26 (1.4) | 200 (1.4) |
| PA2572 | Probable two-component response regulator | 2.3 | 2.8 (1.4) | 3.3 (1.4) |
| PA2573 | Probable chemotaxis transducer | 2.3 | 4.1 (1.4) | 3.9 (1.4) |
| PA2587 | qsc105, probable FAD-dependent monooxygenase | 12 | 12 (0.2) | 15 (0.1) |
| PA2588 | Probable transcriptional regulator | 15 | 22 (0.2) | 46 (0.8) |
| PA2591 | Probable transcriptional regulatore | 21 | 25 (0.2) | 42 (0.2) |
| PA2592 | qsc104, probable spermidine-putrescine-binding proteine | 5.6 | 8.7 (0.4) | 15 (0.8) |
| PA2593 | Hypothetical protein | NC | 4.6 (2.0) | 29 (0.8) |
| PA2717 | cpo, chloroperoxidase precursor | 2.4 | 2.6 (2.0) | 3.4 (1.4) |
| PA2747 | Hypothetical protein | 3.6 | 7.2 (2.0) | 11 (2.0) |
| PA2927 | Hypothetical protein | 2.6 | 3.4 (2.0) | 14 (1.4) |
| PA2939 | Probable aminopeptidase | 38 | 42 (1.4) | 27 (1.4) |
| PA3022 | Hypothetical protein | 3.5 | 4.7 (2.0) | 4.3 (2.0) |
| PA3032 | qsc135, cytochrome c | 2.3 | 3.3 (2.0) | 9.3 (2.0) |
| PA3104 | xcpP, secretion protein XcpP | 3.1 | 3.2 (2.0) | 4.7 (1.4) |
| PA3181 | 2-Keto-3-deoxy-6-phosphogluconate aldolase | 1.6 | 2.9 (3.0) | 3.2 (3.0) |
| PA3182 | Conserved hypothetical protein | 1.7 | 3.2 (3.0) | 5.0 (3.0) |
| PA3183 | zwf, glucose-6-phosphate 1-dehydrogenase | 2.0 | 3.7 (3.0) | 4.0 (3.0) |
| PA3188 | Probable permease of ABC sugar transporter | 2.9 | 4.2 (2.0) | 6.8 (3.0) |
| PA3189 | Probable permease of ABC sugar transporter | 2.0 | 2.5 (3.0) | 3.0 (3.0) |
| PA3190 | Probable component of ABC sugar transporter | 2.7 | 3.4 (2.0) | 4.1 (3.0) |
| PA3194 | edd, phosphogluconate dehydratase | 2.0 | 3.2 (3.0) | 2.9 (3.0) |
| PA3195 | gapA, glyceraldehyde-3-phosphate dehydrogenase | 3.1 | 5.0 (3.0) | 5.4 (3.0) |
| PA3274 | Hypothetical proteind | 1.9 | 4.3 (2.0) | 10 (2.0) |
| PA3311 | Conserved hypothetical protein | 3.6 | 3.6 (2.0) | 6.0 (1.4) |
| PA3326 | Probable Clp family ATP-dependent proteasee | 6.6 | 20 (0.4) | 19 (0.8) |
| PA3327 | qsc126, probable nonribosomal peptide synthetasee | NC | 6.8 (0.8) | 20 (0.8) |
| PA3328 | qsc125, probable FAD-dependent monooxygenase | NC | 17 (0.4) | 47 (0.8) |
| PA3329 | qsc124, hypothetical protein | NC | 250 (0.4) | 310 (0.8) |
| PA3330 | qsc123, probable short-chain dehydrogenase | NC | 120 (0.4) | 320 (0.8) |
| PA3331 | qsc122, cytochrome P450 | 3.5 | 39 (0.4) | 62 (0.8) |
| PA3332 | Conserved hypothetical protein | 2.3 | 35 (0.8) | 41 (1.4) |
| PA3333 | qsc121, fabH2, 3-oxoacyl-(acyl carrier protein) synthase III | NC | 32 (0.4) | 64 (0.8) |
| PA3334 | Probable acyl carrier protein | 1.8 | 49 (0.4) | 69 (0.8) |
| PA3335 | Hypothetical protein | NC | 9.6 (0.4) | 29 (1.4) |
| PA3336 | qsc120, probable MFS transporter | NC | 22 (1.4) | 24 (0.8) |
| PA3346 | Probable two-component response regulator | 2.7 | 2.8 (2.0) | 4.7 (2.0) |
| PA3347 | Hypothetical proteinc | 2.3 | 2.8 (2.0) | 4.3 (1.4) |
| PA3361 | Hypothetical protein | 10 | 13 (1.4) | 68 (1.4) |
| PA3369 | Hypothetical protein | 1.9 | 3.3 (2.0) | 4.8 (2.0) |
| PA3370 | Hypothetical protein | 1.7 | 3.5 (2.0) | 5.6 (2.0) |
| PA3371 | Hypothetical protein | 1.7 | 3.6 (2.0) | 6.0 (2.0) |
| PA3416 | Probable pyruvate dehydrogenase component | 2.5 | 3.2 (2.0) | 4.1 (1.4) |
| PA3418 | ldh, leucine dehydrogenase | 2.6 | 3.7 (1.4) | 5.0 (1.4) |
| PA3476 | qsc118, rhlI, autoinducer synthesis protein RhlIe | NCf | NCf | 34 (0.05) |
| PA3477 | rhlR, transcriptional regulator RhlR | 8.5 | 9.6 (0.4) | 130 (0.05) |
| PA3478 | qsc119,rhlB, rhamnosyltransferase chain B | 5.3 | 89 (0.8) | 120 (1.4) |
| PA3479 | qsc119,rhlA, rhamnosyltransferase chain Ae | 10 | 120 (0.8) | 200 (0.8) |
| PA3520 | Hypothetical proteind | 2.2 | 13 (1.4) | 32 (1.4) |
| PA3535 | Probable serine protease | 7.5 | 8.1 (0.4) | 5.9 (0.8) |
| PA3676 | Probable RND efflux transporter | 3.9 | 1.9 (2.0) | 5.8 (1.4) |
| PA3677 | Probable RND efflux protein precursor | 3.6 | 3.8 (2.0) | 8.3 (1.4) |
| PA3678 | Probable transcriptional regulator | 2.9 | 1.6 (2.0) | 3.5 (1.4) |
| PA3688 | Hypothetical protein | 3.0 | 5.4 (0.2) | 3.5 (1.4) |
| PA3691 | Hypothetical protein | 2.4 | 4.5 (2.0) | 6.3 (2.0) |
| PA3692 | Probable outer membrane protein | 3.0 | 5.8 (2.0) | 6.9 (2.0) |
| PA3724 | lasB, elastase LasBe | 110 | 180 (0.8) | 240 (0.8) |
| PA3734 | Hypothetical protein | NC | 4.1 (3.0) | 16 (2.0) |
| PA3888 | Probable permease of ABC transporter | NC | 3.2 (2.0) | 3.9 (2.0) |
| PA3890 | Probable permease of ABC transporter | 1.8 | 4.1 (2.0) | 4.7 (2.0) |
| PA3891 | Probable component of ABC transporter | 2.1 | 5.0 (2.0) | 8.2 (2.0) |
| PA3904 | Hypothetical protein | 49 | 42 (0.2) | 46 (0.05) |
| PA3905 | Hypothetical protein | 37 | 59 (0.2) | 87 (0.05) |
| PA3906 | Hypothetical protein | 140 | 130 (0.2) | 71 (0.05) |
| PA3907 | qsc103, hypothetical protein | 20 | 19 (0.2) | 58 (0.05) |
| PA3908 | Hypothetical protein | 10 | 11 (0.2) | 55 (0.05) |
| PA3986 | Hypothetical protein | 2.7 | 3.3 (1.4) | 2.8 (2.0) |
| PA4078 | qsc134, probable nonribosomal peptide synthetased | 3.2 | 4.6 (2.0) | 20 (2.0) |
| PA4117 | Probable bacteriophytochrome | 5.3 | 5.6 (1.4) | 4.3 (1.4) |
| PA4129 | Hypothetical protein | 25 | 31 (0.8) | 15 (0.8) |
| PA4130 | Probable sulfite or nitrite reductase | 23 | 27 (0.8) | 1 (0.8) |
| PA4131 | Probable iron-sulfur protein | 24 | 30 (0.8) | 21 (0.8) |
| PA4132 | Conserved hypothetical protein | 14 | 15 (0.8) | 6.4 (0.8) |
| PA4133 | Cytochrome c oxidase subunit (cbb3 type) | 100 | 100 (0.8) | 37 (0.8) |
| PA4134 | Hypothetical protein | 43 | 47 (0.8) | 21 (0.8) |
| PA4139 | Hypothetical protein | 3.1 | 2.9 (2.0) | 3.9 (2.0) |
| PA4141 | Hypothetical protein | 2.6 | 26 (0.4) | 73 (1.4) |
| PA4142 | Probable secretion protein | NC | 5.2 (2.0) | 16 (1.4) |
| PA4171 | Probable protease | 3.5 | 4.6 (2.0) | 5.1 (2.0) |
| PA4172 | Probable nuclease | 2.0 | 3.4 (2.0) | 14 (2.0) |
| PA4175 | Probable endoproteinase Arg-C precursor | 11 | 15 (2.0) | 23 (1.4) |
| PA4190 | Probable FAD-dependent monooxygenase | 3.0 | 2.5 (1.4) | 4.0 (0.2) |
| PA4205 | Hypothetical protein | 1.9 | 8.7 (3.0) | 56 (2.0) |
| PA4206 | Probable RND efflux protein precursor | 1.7 | 6.3 (3.0) | 30 (2.0) |
| PA4207 | qsc133, probable RND efflux transporter | NC | 2.5 (3.0) | 17 (2.0) |
| PA4208 | Probable outer membrane efflux protein | 1.6 | 3.1 (3.0) | 19 (2.0) |
| PA4209 | Probable O-methyltransferasee | 4.6 | 11 (1.4) | 27 (1.4) |
| PA4210 | Probable phenazine biosynthesis proteine,g | NC | 59 (1.4) | 71 (1.4) |
| PA4211 | Probable phenazine biosynthesis proteind | 10 | 69 (0.8) | 220 (0.8) |
| PA4212 | qsc131, phenazine biosynthesis protein PhzCd | 2.2 | 15 (1.4) | 77 (1.4) |
| PA4213 | Phenazine biosynthesis protein PhzD | 3.7 | 36 (1.4) | 210 (1.4) |
| PA4214 | Phenazine biosynthesis protein PhzE | 2.5 | 18 (1.4) | 59 (1.4) |
| PA4215 | Probable phenazine biosynthesis protein | 3.1 | 24 (1.4) | 110 (1.4) |
| PA4216 | Probable pyridoxamine 5-phosphate oxidase | 3.0 | 21 (1.4) | 56 (1.4) |
| PA4217 | qsc132, probable FAD-dependent monooxygenase | 4.4 | 28 (1.4) | 41 (1.4) |
| PA4296 | Probable two-component response regulator | 2.4 | 3.6 (1.4) | 5.6 (1.4) |
| PA4297 | Hypothetical protein | 2.4 | 3.3 (2.0) | 12 (2.0) |
| PA4298 | Hypothetical protein | 2.3 | 4.7 (2.0) | 8.7 (2.0) |
| PA4299 | Hypothetical protein | 2.1 | 3.6 (2.0) | 7.0 (2.0) |
| PA4300 | Hypothetical protein | 2.0 | 3.5 (2.0) | 7.8 (2.0) |
| PA4302 | Probable type II secretion system protein | 3.2 | 6.1 (2.0) | 7.4 (2.0) |
| PA4304 | Probable type II secretion system protein | 2.2 | 3.1 (2.0) | 6.1 (2.0) |
| PA4305 | Hypothetical protein | 2.1 | 2.7 (2.0) | 5.9 (2.0) |
| PA4306 | Hypothetical protein | 10 | 16 (1.4) | 38 (1.4) |
| PA4311 | Conserved hypothetical protein | 2.5 | 3.2 (2.0) | 2.6 (2.0) |
| PA4384 | Hypothetical protein | NC | 2.7 (3.0) | 4.0 (3.0) |
| PA4498 | Probable metallopeptidase | 1.6 | 4.5 (3.0) | 9.1 (3.0) |
| PA4590 | pra, protein activator | 9.3 | 14 (1.4) | 13 (0.8) |
| PA4648 | Hypothetical protein | 3.4 | 7.7 (2.0) | 17 (1.4) |
| PA4649 | Hypothetical protein | NC | 3.2 (2.0) | 7.4 (1.4) |
| PA4650 | Hypothetical protein | NC | 3.3 (2.0) | 8.8 (2.0) |
| PA4651 | Probable pilus assembly chaperoned | NC | 4.6 (2.0) | 15 (2.0) |
| PA4652 | Hypothetical protein | 6.0 | 13 (2.0) | 9.6 (2.0) |
| PA4677 | Hypothetical protein | 16 | 13 (0.2) | 36 (0.1) |
| PA4703 | Hypothetical protein | 3.1 | 4.3 (2.0) | 3.5 (1.4) |
| PA4738 | Conserved hypothetical protein | 3.8 | 9.1 (2.0) | 11 (2.0) |
| PA4739 | Conserved hypothetical protein | 4.2 | 9.4 (2.0) | 14 (2.0) |
| PA4778 | Probable transcriptional regulator | 5.4 | 4.9 (0.4) | 8.6 (0.1) |
| PA4869 | qsc106, hypothetical proteind | 5.0 | 5.7 (0.4) | 3.8 (0.1) |
| PA4876 | osmE, osmotically inducible lipoprotein OsmE | 2.3 | 3.6 (2.0) | 4.9 (2.0) |
| PA4880 | Probable bacterioferritin | 2.2 | 4.6 (2.0) | 5.8 (2.0) |
| PA4916 | Hypothetical protein | 1.5 | 4.3 (4.0) | 6.1 (2.0) |
| PA4917 | Hypothetical proteind | 1.4 | 5.8 (2.0) | 7.7 (2.0) |
| PA4925 | Conserved hypothetical protein | 3.8 | 3.7 (2.0) | 5.7 (1.4) |
| PA5027 | Hypothetical proteine | 1.5 | 2.8 (2.0) | 3.2 (3.0) |
| PA5058 | phaC2, poly(3-hydroxyalkanoic acid) synthase 2e | 4.5 | 4.7 (1.4) | 9.2 (1.4) |
| PA5059 | Probable transcriptional regulator | 4.4 | 5.9 (2.0) | 9.3 (1.4) |
| PA5061 | Conserved hypothetical protein | 1.7 | 2.5 (4.0) | 2.6 (4.0) |
| PA5161 | rmlB, dTDP-d-glucose 4,6-dehydratase | NC | 2.9 (4.0) | 5.9 (3.0) |
| PA5162 | rmlD, dTDP-4-dehydrorhamnose reductase | NC | 2.5 (4.0) | 4.9 (3.0) |
| PA5164 | rmlC, dTDP-4-dehydrorhamnose 3,5-epimerase | NC | 2.6 (3.0) | 5.6 (2.0) |
| PA5220 | qsc138, hypothetical protein | 2.8 | 18 (0.8) | 26 (1.4) |
| PA5352 | Conserved hypothetical protein | 2.0 | 2.8 (1.4) | 2.9 (1.4) |
| PA5353 | glcF, glycolate oxidase subunit GlcF | 1.9 | 3.4 (1.4) | 3.5 (1.4) |
| PA5354 | glcE, glycolate oxidase subunit GlcE | 2.0 | 2.6 (1.4) | 3.2 (1.4) |
| PA5355 | glcD, glycolate oxidase subunit GlcD | 2.1 | 3.6 (1.4) | 3.8 (1.4) |
| PA5356 | qsc130, glcC, transcriptional regulator GlcC | 2.4 | 4.1 (1.4) | 2.8 (1.4) |
| PA5415 | glyA1, serine hydroxymethyltransferase | 2.6 | 2.8 (3.0) | 5.0 (3.0) |
| PA5481 | Hypothetical protein | 4.1 | 11 (2.0) | 15 (1.4) |
| PA5482 | Hypothetical protein | 5.4 | 15 (2.0) | 18 (1.4) |
a
Gene number from the Pseudomonas genome project (http://www.pseudomonas.com).
b
Boldface type indicates genes or gene products previously reported to be controlled by quorum sensing. RND, resistance-nodulation-cell division; FAD, flavin adenine dinucleotide.
c
Maximum changes (fold) in gene expression (rounded to two significant figures) in the signal generation mutant in the presence of the signal(s) indicated compared with the absence of signal and in the wild-type P. aeruginosa strain compared with the receptor mutant. The values in parentheses are the OD600 at which the earliest change of ≥2.5-fold was observed (for the signal generation mutant both time courses were considered). NC, no change.
d
There is a las-rhl box-like sequence with an HI of ≥10 and <13.
e
There is a las-rhl box-like sequence with an HI of <10.
f
The transcript levels for lasI and rhlI were close to the background level in the signal generation mutant due to the disruption of both loci by insertional mutagenesis.
g
The GeneChip probes for PA4210 to PA4216 are identical to those for PA1899 to PA1905. Although the sequences for the genes in these two clusters are almost identical, the region upstream of PA4210 contains a las-rhl box-like sequence, but the region upstream of PA1899 does not.