FIG. 3.

p53 deficiency rescues lymphopoietic defects in mdm2^puro/Δ7-12 mice. (A) Percentage of apoptotic cells in the lymphoid compartment of wild-type, mdm2^puro/Δ7-12, and mdm2^puro/Δ7-12 p53^−/− mice. Freshly isolated bone marrow and thymocytes were stained for the indicated B- and T-cell markers, respectively, incubated with annexin V and propidium iodide (PI), and analyzed by flow cytometry. DN, double negative; DP, double positive. (B) Thymuses from wild-type, mdm2^puro/Δ7-12, and mdm2^puro/Δ7-12 p53^−/− mice. (C) Average number of B220⁺ bone marrow cells per two femurs from wild-type, mdm2^puro/Δ7-12, and mdm2^puro/Δ7-12 p53^−/− mice.