Abstract
If phenylketonuria is diagnosed during the first few weeks of life, a special diet can be given to prevent the brain damage that otherwise will occur.
A simple, cheap, accurate laboratory test has been developed to diagnose the condition in infants two to four days old before they leave the hospital.
At the Donald N. Sharp Memorial Community Hospital in San Diego routine testing of all newborn infants has been done with this technique since August 26, 1963. Mass screening programs in the newborn nursery are already being carried out by large numbers of hospitals across the United States.
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Selected References
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- BAIRD H. W., 3rd A reliable paper-strip method for the detection of phenylketonuria. J Pediatr. 1958 Jun;52(6):715–717. doi: 10.1016/s0022-3476(58)80272-3. [DOI] [PubMed] [Google Scholar]
- BERRY H. K. Paper chromatographic method for estimation of phenylalanine. Proc Soc Exp Biol Med. 1957 May;95(1):71–73. doi: 10.3181/00379727-95-23124. [DOI] [PubMed] [Google Scholar]
- HSIA D. Y., LITWACK M., O'FLYNN M., JAKOVCIC S. Serum phenylalanine and tyrosine levels in the newborn infant. N Engl J Med. 1962 Nov 22;267:1067–1070. doi: 10.1056/NEJM196211222672104. [DOI] [PubMed] [Google Scholar]
- LA DU B. N., MICHAEL P. J. An enzymatic spectrophotometric method for the determination of phenylalanine in blood. J Lab Clin Med. 1960 Mar;55:491–496. [PubMed] [Google Scholar]
- WOOLF L. I. INHERITED METABOLIC DISORDERS: ERRORS OF PHENYLALANINE AND TYROSINE METABOLISM. Adv Clin Chem. 1963;6:97–230. doi: 10.1016/s0065-2423(08)60239-5. [DOI] [PubMed] [Google Scholar]