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In vivo neutralization of (a) mMIP-2/CXCL2/3, (b) mKC/CXCL1, and (c) mKC/CXCL1 + mMIP-2/CXCL2/3 (as compared with treatment with control antibodies) attenuates VILI, as demonstrated by VILI scores of H&E-stained histopathologic sections from mice placed on high peak pressure/stretch. A cumulative score was based on leukocyte infiltration, exudative edema, hemorrhage, and alveolar wall thickness (n = 6; two random sections per lung and three lungs per group). *P < 0.05.
