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. 2003 Mar;23(5):1633–1646. doi: 10.1128/MCB.23.5.1633-1646.2003

FIG. 2.

FIG. 2.

(A) Binding of E2 to the nuclei and membranes of CHO cells expressing either HE11G (A/B domain deleted), HE19G (C domain deleted), or HEG0-537 (helix 12 and F domain deleted) ERα or wt ERα. The study was repeated. (B) ERK activation in response to E2 in CHO cells expressing either wt ERα or a deletion mutant. Activity was determined after 8 min of incubation with 10 nM E2. MBP was used as a substrate for ERK activity. Total ERK protein is shown on the immunoblot beneath the activity results.