FIG.8.

Model depicting the ordered recruitment of chromatin-modifying and basal factors to the collagenase promoter. Shortly after TPA and 20% serum treatment, c-Jun, c-Fos, TBP, RNA polymerase II, and SET9 assemble on the collagenase promoter and histones are first dimethylated and later trimethylated. Next, p300 and RSK2 are recruited, and this event correlates with the appearance of acetylated and phosphorylated nucleosomes. Finally, SWI/SNF associates with the promoter, thereby completing PIC formation, resulting in initiation of transcription.