TABLE 3.
GPx1 levels in various tissues of Trspfl/fl, Trspfl/fl-MMTV-Cre, and Trspfl/fl-WAP-Cre mice
| Tissue | Genotype | Mean GPx1 activitya (nmol of NADPH oxidized/min) ± SD | % of control |
|---|---|---|---|
| Mammary | Trspfl/fl (control) | 47.9 ± 3.3 | |
| Trspfl/fl-MMTV-Cre | 14.1 ± 6.6 | 29.4 | |
| Trspfl/fl-WAP-Cre | 18.0 ± 6.8 | 37.6 | |
| Skin (ear) | Trspfl/fl | 70.5 ± 9.1 | |
| Trspfl/fl-MMTV-Cre | 54.2 ± 4.8 | 76.9 | |
| Trspfl/fl-WAP-Cre | 79.6 ± 15.8 | 112.9 | |
| Spleen | Trspfl/fl | 50.8 ± 10.5 | |
| Trspfl/fl-MMTV-Cre | 34.0 ± 7.2 | 66.9 | |
| Trspfl/fl-WAP-Cre | 56.9 ± 9.5 | 112.0 | |
| Kidney | Trspfl/fl | 164.9 ± 22.2 | |
| Trspfl/fl-MMTV-Cre | 158.0 ± 18.2 | 95.8 | |
| Trspfl/fl-WAP-Cre | 155.3 ± 16.8 | 94.2 |
a
Biochemical assays of GPx1 were carried out in triplicate as given previously (37).