FIG. 1.

(A) Schematic representation of the two-step mechanism of PacC proteolytic activation. The different regions in PacC are indicated by boxes, with numbers denoting amino acid residues. Region C of Espeso et al. (10) is divided into regions C and D (also see the text). To avoid confusion with previous publications, residues are numbered as if translation proceeded from methionine codon 1, although translation proceeds from methionine codon 5 (25). (B) Subdivision of the 150 C-terminal residues into regions C and D by nested deletion analysis.