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Conserved interactions between PalA/AIP1/Alix family members, YPXL/I-containing proteins, and the Vps endocytotic machinery. 2H indicates two-hybrid, and CoIP indicates coimmunoprecipitation (46). The dotted line indicates that interaction is deduced from heterologous interaction between human AIP1/Alix and the A. nidulans Vps32 homologue. The Bro1p-Vps4p-Vps32p complex was isolated by Gavin et al. (14) and agrees with two-hybrid assay data (15, 41).
