TABLE 1.

Pharmacokinetic parameters of florfenicol following i.v., i.m., or p.o. administration of a single dose of 20 mg/kg in healthy and A. pleuropneumoniae-infected pigs

Parameterb	Value for indicated group and method of administrationa
	i.v.		i.m.		p.o.
	Healthy	Infectedc	Healthy	Infectedc	Healthy	Infectedc
Cmax (μg/ml)			3.20 ± 0.61	4.00 ± 0.76	10.84 ± 2.71	8.11 ± 2.72
Tmax (μg/ml)			0.91 ± 0.32	0.78 ± 0.27	1.35 ± 0.71	1.92 ± 0.54
t1/2α (h)	0.64 ± 0.39	0.37 ± 0.29	0.15 ± 0.02	0.12 ± 0.05	2.87 ± 1.64	3.91 ± 1.4
t1/2β (h)	2.63 ± 0.51	2.91 ± 0.81	14.27 ± 2.69	13.88 ± 4.09	12.39 ± 7.23	16.53 ± 4.21
V (liter/kg)	1.17 ± 0.32	1.41 ± 0.93
Vss (liter/kg)	0.95 ± 0.07	1.20 ± 0.39
CL (liter/kg/h)	0.31 ± 0.02	0.32 ± 0.07
CL/F (liter/kg/h)			0.30 ± 0.02	0.26 ± 0.06	0.31 ± 0.02	0.28 ± 0.06
AUC0-∞ (μg · h/ml)	66.17 ± 7.13	64.86 ± 14.43	68.61 ± 10.36	79.63 ± 26.8	65.89 ± 12.79	73.28 ± 14.67
F (%)			103.74 ± 26.75	122.77 ± 44.43	99.57 ± 19.33	112.9 ± 8.82
tcp(ther)d (h)	14.50 ± 1.39	15.95 ± 3.15	53.0 ± 10.53	53.88 ± 19.2	21.83 ± 10.28	22.78 ± 8.81

^aValues are means ± standard deviations (n = 6).

^bCL, clearance; F, bioavailability; the other abbreviations are defined in the text.

^cNo significant difference compared with results for the healthy group (two-tailed t test, P < 0.05).

^dBased on the average MIC of 0.25 μg/ml for A. pleuropneumoniae in pigs (6).