TABLE 2.
Characteristics of three telithromycin-resistant S. pyogenes strainsa
| Strain | Town | Federal state | Source | MIC (μg/ml)
|
Resistance genotype | MLSTb | emm type | L22 (rplV) | L4 | rrl D2 (23S rRNA) | rrl D5a (23S rRNA) | rrl D5b (23S rRNA) | erm(B) (ORF Tn917) | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TEL | ERY | CLI | |||||||||||||
| PY31 | Bad Hersfeld | HE | Throat | 4 | 32 | 1 | erm(B) | 52 | 28 | WT | WT | WT | T2166C | WT | WT |
| PY152 | Neukirchen | SN | Throat | 16 | 32 | 0.25 | erm(B) | 52 | 28 | WT | WT | WT | T2166C | WT | WT |
| PY178 | Trier | RP | Throat | 8 | 32 | 32 | erm(B) | 52 | 28 | WT | WT | WT | T2166C | WT | WT |
a
Abbreviations: HE, Hessen; SN, Saxony; RP, Rhineland Pfalz, TEL, telithromycin, ERY, erythromycin; CLI, clindamycin; MLST, multilocus sequence type, WT, wild type; ORF, open reading frame.
b
All strains showed MLST 52 with the following alleles: gki-11, gtr-6, murl-14, mutS-5, recP-9, xpt-17, and yqiL-19.