TABLE 1.
Serum and lung tigecycline concentrations and pharmacokinetic estimates for normal guinea pigs given the indicated doses
| Parameter | Valuea at dosage (mg/kg) of:
|
|||
|---|---|---|---|---|
| 7.5 for 5 days | 7.5 for 10 days | 7.5 BID for 5 days | 3.75 for 5 days | |
| Time postdose (h) | ||||
| 0.5 | 1.9/1.3 | 6.9/3.9 | 3.7/2.4 | 2.3/1.9 |
| 1 | 4.1/2.4 | 6.2/3.4 | 3.8/2.9 | 2.2/2.2 |
| 2 | 2.9/2.8 | 3.5/3.3 | 3.6/3.5 | 2.1/1.7 |
| 4 | 2.1/2.0 | 1.8/1.8 | 2.4/2.8 | 1.1/1.0 |
| 6 | 1.1/0.99 | 0.99/1.1 | 1.5/1.4 | 0.69/0.9 |
| 8 | 1/0.88 | 0.57/1.0 | 1.6/1.3 | 0.58/0.62 |
| 24 | 0.25/0.13 | 0.06/ND | 0.33/0.11 | 0.07/ND |
| AUC0-24 (μg · h/ml) | 28.7/22.7 | 24.9/21.3 | 38.4/30.3 | 15.8/13.1 |
| Half-life (h) | 8.2/6.0 | 4.6/3.5 | 7.4/4.7 | 5.4/3.9 |
a
Serum (micrograms per milliliter)/lung (micrograms per gram); n = 2 for each datum point. BID, twice a day; ND, not done.