TABLE 2.
L. pneumophila lung clearance from infected guinea pigs treated with tigecycline
| Treatment dosage (mg/kg)a | Log10 CFU/g on postinfection dayb:
|
||||
|---|---|---|---|---|---|
| 2 | 6 | 8 | 10 | 12 | |
| 7.5 (5 days) | 6.7 | 4.8 (3.3-5.1; 4)b | 6.2 (5.6-6.6; 4) | 5.7 (4.8-6.0; 2) | |
| 7.5 (9 days) | 4.8 | 5.5 (2.3-5.4; 6) | 4.9 (4.4-5.9; 4) | ||
| 15 (day 1); 7.5 (4 days) | 4.8 (3.5-5.4; 4) | 6.6 (5.1-7.0; 3) | 4.8 (4.4-5.1; 4) | ||
| 3.75 BID (5 days) | 6.9 (6.4-7.2; 2) | 4.2 (3.3-4.5; 3) | 5.7 (5.6-5.9; 3) | 5.9 (5.7-6.1; 3) | |
| Saline | 9.3 (9.0-9.6; 4) | ||||
a
BID, given twice daily.
b
Mean (range; n); for cases where n = 1, no range or n is given.