TABLE 1.
Effect of cell line on MIC, MCC, and MCC3 for C. trachomatis serovar Da
| Cell type (origin) | Doxycycline
|
Azithromycin
|
Erythromycin
|
Ofloxacin
|
Tetracycline
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MIC | MCC | MCC3 | MIC | MCC | MCC3 | MIC | MCC | MCC3 | MIC | MCC | MCC3 | MIC | MCC | MCC3 | |
| McCoy (human) | 0.064 | >8 | 64 | 0.125 | >8 | 64 | 0.25 | >8 | 128 | 1 | >8 | 128 | 0.25 | >8 | 64 |
| HeLa (human) | 0.064 | 1 | 4 | 0.016 | 1 | 8 | 0.032 | 2 | 4 | 1 | 4 | 16 | 0.25 | 2 | 16 |
| BGMK (simian) | 0.064 | >8 | 64 | 1.0 | >8 | 64 | 2 | >8 | 128 | 1 | >8 | 128 | 0.25 | >8 | 64 |
| HEp-2 (human) | 0.064 | 1 | 4 | 0.064 | 4 | 32 | 0.125 | 4 | 8 | 1 | 4 | 64 | 0.25 | 4 | 32 |
| HL (human) | 0.064 | 2 | 32 | 0.008 | 4 | 32 | 0.016 | 4 | 0.5 | 1 | 8 | 32 | 0.25 | 4 | 32 |
| Vero (simian) | 0.064 | 2 | 8 | 0.25 | 2 | 4 | 0.5 | 4 | 16 | 1 | 8 | 32 | 0.25 | 2 | 16 |
a
All values are in micrograms per milliliter. The MIC was defined as one twofold dilution more than the MICTP; MCC, minimal chlamydicidal concentration following one freeze-thaw passage in microtiter plates; MCC, minimal chlamydicidal concentration following one passage in shell vials; MCC3, minimal chlamydicidal concentration following three passages in shell vials.