TABLE 2.
Effect of inoculum size on doxycycline MIC, MCC, and MCC3 for C. trachomatis serovar Da
| Inoculum (103 IFU/well) | MIC | MCC | MCC3 |
|---|---|---|---|
| 320 | 0.064 | >8 | 64 |
| 160 | 0.064 | >8 | 64 |
| 80 | 0.064 | >8 | 64 |
| 40 | 0.064 | >8 | 64 |
| 20 | 0.064 | >8 | 64 |
| 10 | 0.064 | >8 | 64 |
| 5 | 0.064 | >8 | 64 |
| 2.5 | 0.064 | 0.064 | 0.064 |
| 1.25 | 0.064 | 0.064 | 0.064 |
| 0.625 | 0.064 | 0.064 | 0.064 |
| 0.3125 | 0.064 | 0.064 | 0.064 |
a
All values are in micrograms per milliliter. The MIC was defined as one twofold dilution more than the MICTP; MCC, minimal chlamydicidal concentration following one freeze-thaw passage in microtiter plates; MCC, minimal chlamydicidal concentration following one passage in shell vials; MCC3, minimal chlamydicidal concentration following three passages in shell vials.