TABLE 3.
Antimicrobial susceptibilities of reference strains of Chlamydia speciesa
| Chlamydia reference strain(s) | Doxycycline
|
Azithromycin
|
Ofloxacin
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Microtiter
|
Shell vial
|
Microtiter
|
Shell vial
|
Microtiter
|
Shell vial
|
|||||||
| MIC | MCC | MCC | MCC3 | MIC | MCC | MCC | MCC3 | MIC | MCC | MCC | MCC3 | |
| C. trachomatis B, D, E, F, G, H, I, Ia, J, and K (human genital serovars) | 0.064 | 0.125 | >8 | 16-32 | 0.125 | 0.25 | >8 | 64 | 0.5 | 1.0 | >8 | >128 |
| C. trachomatis L2 (LGV serovar) | 0.064 | 0.125 | >8 | 32 | 0.125 | 0.25 | >8 | 64 | 0.5 | 1.0 | >8 | >128 |
| C. trachomatis MoPn (mouse pneumonitis strain) | 0.064 | 0.5 | >8 | 64 | 0.125 | 0.5 | >8 | 128 | 0.5 | 1.0 | >8 | >128 |
| C. suis R-19 (porcine strain)b | 1.0 | 2.0 | >8 | >128 | 0.125 | 0.25 | >8 | >128 | 0.5 | 1.0 | >8 | >128 |
| C. pneumoniae TW-183, CWL-029c | 0.064 | 0.125 | 4-8 | 32-64 | 0.125 | 0.25 | 4-8 | 64 | 0.5 | 1.0 | >8 | >128 |
| C. psittaci 6BC, GPIC | 0.064 | 0.250 | >8 | >128 | 0.125 | 0.50 | >8 | >128 | 0.5 | 2.0 | >8 | >128 |
a
All values are in micrograms per milliliter. The MIC was defined as one twofold dilution more than the MICTP; MCC, minimal chlamydicidal concentration following one freeze-thaw passage in microtiter plates; MCC, minimal chlamydicidal concentration following one passage in shell vials; MCC3, minimal chlamydicidal concentration following three passages in shell vials.
b
Tetracycline-resistant (MIC, >4 μg/ml) porcine strain provided by Arthur A. Andersen, National Animal Disease Center, Ames, Iowa.
c
C. pneumoniae strains grown in HEp-2 cells.