FIG. 4.

Effect of inhibitors on HIV-1 vector virus. RT inhibitors and indinavir were incubated with producer cells (at the time of induction with 10 μM ponasterone A until harvest of the supernatant on day 4) or target cells (added at the time of infection along with 8 μg of Polybrene per ml and maintained through the addition of 1 μg of puromycin per ml with 10% MEM during the selection process). Results shown are the means (± standard deviations) of quadruplicate titer determinations. The control consisted of producer or target cells not treated with protease and RT inhibitors. AZT, zidovudine; ddI, didanosine; 3TC, lamivudine; d4T, stavudine.