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. 2003 Feb;47(2):467–474. doi: 10.1128/AAC.47.2.467-474.2003

FIG. 4.

FIG. 4.

TEM of E. multilocularis metacestode tissue fixed at 4 to 6 days of NTZ treatment. (A) Four days of NTZ exposure results in partial loss of microtriches (arrow), increased vacuolization (vac), loss of cell-cell contacts, and accumulation of lipid droplets (lip) within the germinal layer. (B) High density of small vesicular bodies within the laminated layer of NZT-treated metacestodes after 4 days of NTZ treatment. (C) Necrotic parasite tissue after 6 days. Note the large amount of cellular debris, the complete absence of microtriches, and the separation of the laminated layer and the tegument (arrow). (D) The white arrows point to rounded mitochondria. Bars, 3 μm (A), 1.7 μm (B), 4.1 μm (C), and 3.9 μm (D). GL, germinal layer; TE, tegument; LL, laminated layer; Mt, microtriches.