TABLE 1.

MICs and falls in viable counts after exposure to the five quinolones in concentrations attainable in human lesions (models 1 and 2)

Quinolone	MIC (mg/liter)	Result for model and quinolone concn (mg/liter)
		Model 1 (100-day culture)			Model 2 (rifampin-tolerant persisters)
		No. of colonies on 2 plates at 0.0	Δ Falla at:		No. of colonies on 2 plates at 0.0	Δ Falla at:
			1.56	3.125		1.56	3.125
Ciprofloxacin	0.500	867	0.026	0.040	766	0.003	0.054
Ofloxacin	0.707	816	0.041	0.117	766	0.019	0.073
Levofloxacin	0.354	857	0.196	0.226	762	0.077	0.181
Moxifloxacin	0.177	884	0.439	0.589	760	0.222	0.466
Gatifloxacin	0.125	812	0.368	0.498	762	0.271	0.536

^aΔ Fall = (log₁₀ CFU/milliliter after no quinolone exposure) − (log₁₀ CFU/milliliter after exposure to 1.56 or 3.125 mg of quinolone/liter). Standard deviations of Δ fall are 0.0134 in model 1 and 0.0903 in model 2.