TABLE 2.
Inhibitory concentrations of RANTES derivatives in virus replication assays
| Cell line | RANTES derivative | Mean IC50, pM (SE) | Correcteda IC50 |
|---|---|---|---|
| MT-2-R5lo | AOP-RANTES | 467 (51) | 467 |
| NNY-RANTES | 343 (134) | 343 | |
| PSC-RANTES | 192 (17) | 192 | |
| MT-2-R5hi | AOP-RANTES | 4,540 (445) | 6,124 |
| NNY-RANTES | 2,780 (333) | 3,750 | |
| PSC-RANTES | 1,740 (189) | 2,347 | |
| MT-2-R5S4A | AOP-RANTES | 3,430 (613) | 1,132 |
| NNY-RANTES | 2,230 (452) | 736 | |
| PSC-RANTES | 956 (97) | 315 | |
| MT-2-R5Δcyt | AOP-RANTES | 26 (12) | 497 |
| NNY-RANTES | 20 (6) | 382 | |
| PSC-RANTES | 35 (5) | 669 |
a
Corrected for p24 antigen concentration (replication efficiency) in untreated control cultures. Virus replication was greatest in MT-2-R5S4A cells and poorest in MT-2-R5Δcyt cells. MT-2-R5lo cells were used as the standard for replication efficiency.