TABLE 1.
Correlation between amino acid substitutions in codon 54 of cyp51A and decreases in azole susceptibility in clinical isolates and spontaneous mutants of A. fumigatus
| Strain | Source of strain | MIC (μg/ml)
|
CYP51A residue 54 | |||
|---|---|---|---|---|---|---|
| POS | ITZ | VOR | AMB | |||
| ND158 | Wild type | 0.03 | 0.12 | 0.25 | 1 | Glycine |
| MS6 | Laboratory mutant | 1 | >16 | 0.12 | 1 | Arginine |
| R1-1 | Laboratory mutant | 1 | >16 | 0.12 | 1 | Arginine |
| R4-1 | Laboratory mutant | 1 | >16 | 0.25 | 1 | Glutamate |
| R6-1 | Laboratory mutant | 1 | >16 | 0.25 | 1 | Glutamate |
| R7-1 | Laboratory mutant | >8 | >16 | 0.25 | 1 | Tryptophan |
| ND215 | Clinical isolate | 0.03 | 0.12 | 0.25 | 2 | Glycine |
| ND216 | Clinical isolate | 0.03 | 0.12 | 0.25 | 2 | Glycine |
| ND267 | Clinical isolate | 0.03 | 0.25 | 0.5 | 2 | Glycine |
| ND223 | Clinical isolate | 1 | >16 | 0.12 | 1 | Arginine |
| ND202 | Clinical isolate | >8 | >16 | 0.12 | 2 | Tryptophan |
| ND229 | Clinical isolate | >8 | >16 | 0.25 | 1 | Tryptophan |