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Mean (and SD) piperacillin concentration-time profile during intermittent infusion (piperacillin, 4 g; tazobactam, 0.5 g; every 6 h) and continuous infusion (piperacillin, 16 g; tazobactam, 2 g; over 24 h) with the MM model. The solid line represents the fit with the MM model based on the intermittent pharmacokinetic data.
