TABLE 3.
Pharmacokinetic parameter estimates obtained by noncompartmental analysisa
| Infusion | AUC0-6 (mg · h/liter) | CL (liters/h) | Vss (liters) | t1/2 (h) |
|---|---|---|---|---|
| Intermittent | 313.0 (56.2) | 13.1 (2.3) | 16.9 (6.1) | 1.2 (0.9) |
| Continuous | 196.0 (83.1) | 24.4 (11.7) | NA | NA |
a
Values are reported as mean (SD). AUC0-6, area under the curve from 0 to 6 h; CL, clearance; Vss, volume of distribution at steady state; t1/2, half-life; NA, not applicable. P values for intermittent infusion versus continuous infusion were <0.001 and <0.02 for AUC0-6 and CL, respectively.