TABLE 4.
Mean pharmacokinetic parameters for targeted patient populationsa
| Parameter | Value
|
||||
|---|---|---|---|---|---|
| ICU patients (n = 94) | Obese patientsb (n = 95) | Oral linezolid therapyc (n = 87) | Elderly patients (n = 74)d | All patients (n = 318) | |
| Vc (liters/65 kg) | 39.8 (25) | 43.9 (18) | 39.3 (19) | 38.2 (21) | 39.6 (23) |
| Vss (liters/65 kg) | 67.7 (24) | 69.7 (18) | 65.1 (25) | 64.2 (22) | 65.8 (23) |
| CLratio | 0.288 (32) | 0.298 (28) | 0.247 (32) | 0.269 (32) | 0.269 (34) |
| Km (μg/ml) | 1.38 (42) | 1.53 (62) | 1.45 (64) | 1.53 (56) | 1.46 (68) |
| CLi (liters/65 kg) | 46.8 (59) | 43.8 (45) | 40.7 (41) | 40.7 (37) | 43.5 (53) |
| Vmax (mg/h/65 kg) | 55.8 (28) | 57.4 (26) | 49.2 (20) | 53.8 (25) | 53.3 (26) |
| AUC (μg/ml · 24 h) | 206 (60) | 210 (56) | 258 (56) | 269 (54) | 228 (58) |
| CLtavg (liters/h/65 kg) | 7.65 (50) | 7.27 (49) | 5.86 (46) | 5.68 (52) | 6.85 (50) |
a
Patients may be represented in more than one category. The CV (percent) is shown in parentheses.
b
Patients were categorized as obese if total body weight was >30% above the calculated IBW.
c
Patients were either started on oral linezolid or switched to oral therapy following initiation of i.v. linezolid.
d
Patients >70 years of age were considered to be elderly.