TABLE 5.

Relationship between AUC and average total clearance

CLtavga	Value when:
	AUC = 100; Cavg = 4.2 μg/ml	AUC = 200; Cavg = 8.3 μg/ml	AUC = 400; Cavg = 17 μg/ml	AUC = 600; Cavg = 25 μg/ml
Minimum	5.4	3.0	1.6	1.2
25th percentile	9.0	5.4	3.2	2.4
Median	10.1	6.3	3.9	3.0
75th percentile	12.0	7.6	4.8	3.7
Maximum	28.4	18.5	12.8	10.8

^aAverage total clearance (in liters per hour per 65 kg) was calculated as the sum of the renal and non renal clearances as follows: CL_tavg = V_max/(K_m + C_avg) + CL_ratio · CL_CR, where C_avg is the average linezolid concentration over days 1 through 7; CL_ratio is defined as the clearance, in liters per hour per 65 kg, by the linear pathway per 1 liter/h/65 kg of CL_CR; and CL_CR is the normalized estimated creatinine clearance. Note that the median CL_tavg decreases by 70% as the AUC increases from 100 to 600 μg/ml·24 h.