TABLE 1.
Pharmacokinetic parameters calculated after the intraperitoneal administration of ceftriaxone (100 mg/kg) to female Sprague-Dawley rats at 0400, 1000, 1600, and 2200 h
| Time (h) of administration | kabs (h−1) | t1/2abs (h) | kel (h−1) | t1/2el (h) | Tlag (h) | V (liter) | CLT (ml/min) | AUC (μg/ml · h) | Tmax (h) | Cmax (μg/ml) |
|---|---|---|---|---|---|---|---|---|---|---|
| 0400 | 19.10 | 0.036 | 0.61 | 1.12 | 0.073 | 0.040 | 0.413 | 436.00 | 0.26 | 240.00 |
| 1000 | 19.70 | 0.035 | 0.64 | 1.08 | 0.035 | 0.027 | 0.285 | 563.00 | 0.21 | 321.00 |
| 1600 | 19.80 | 0.036 | 0.74 | 0.93 | 0.00001 | 0.033 | 0.406 | 423.00 | 0.17 | 276.00 |
| 2200 | 30.60 | 0.022 | 1.28 | 0.54 | 0.054 | 0.025 | 0.532 | 337.00 | 0.16 | 376.00 |