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. 2002 Nov 15;110(10):1419–1427. doi: 10.1172/JCI15582

Figure 2.

Figure 2

Severe joint inflammation is seen in hTNFtg and c-fos–/–hTNFtg mice, but no signs of bone erosions are found in c-fos–/–hTNFtg mice. H&E-stained sections of a digital joint of an hTNFtg (a), a c-fos–/–hTNFtg (b), a wild-type (WT) (c), and a c-fos–/– mouse (d). Inflammatory tissue (indicated by black arrows) and erosion (indicated by a green arrow) are present in the hTNFtg mice. c-fos–/–hTNFtg mice show only inflammatory tissue (black arrows) and no erosions. Wild-type and c-fos–/– mice lack any signs of inflammation and served as controls. Magnification: ×50.