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mPGES-1 is an essential component for PGE2 production in the postischemic cortex. (A) The production of PGE2 in the ipsilateral (i) or contralateral (c) cortex of mPGES-1 KO (−/−) and WT (+/+) mice 24 h after MCAO and sham operation. n = 8 animals per group; ∗∗, P < 0.01 vs. another sample. (B) Western blot analyses for mPGES-1, COX-2, COX-1, cPGES, and mPGES-2 in the cortex 24 h after transient ischemia. Representative immunoblots from three separate experiments are presented.
