Fig. 6.

i.c.v. injection of PGE₂ exaggerated postischemic symptoms in mPGES-1 KO mice. (A) Representative 2,3,5-triphenyltetrazolium chloride (TTC)-stained coronal sections (3 mm from the prefrontal) from PGE₂-injected (5 ng) or vehicle-injected (CONT) mice brain 24 h after ischemia (MCAO) or sham operation. (Scale bar: 5 mm.) (B and C) The corrected volume of infarcted brain tissue (B) and the corrected edema percentage (C) were measured from PGE₂-injected (2.5 or 5 ng) or vehicle-injected (CONT) injected mice brain 24 h after ischemia (MCAO) or sham operation and expressed as a percentage of the total volume. (D and E) The neurological score (D) and the motor activity (E) were measured 24 h after ischemia (MCAO) or sham operation. For B–E, n = 7–10; ∗∗, P < 0.01; ∗, P < 0.05 vs. CONT.