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. 2003 Mar 1;111(5):701–706. doi: 10.1172/JCI17321

Figure 1.

Figure 1

Resistance to collagen-induced arthritis by ICOS-deficient mice. ICOS–/– and ICOS+/+ mice on DBA/1 background were immunized at the base of the tail on days 0, 21, and 42 with type II chicken collagen in CFA. (a) Disease severity was scored on days 38, 42, 47, 48, 50, 55, and 58 by visual inspection of mouse paws. Each paw was scored for the degree of inflammation on a scale 0–4 as indicated in Methods. Scores were then added together. The data shown are a representative of two experiments on a total of more than ten mice in each group, with similar results. (b) Representative photos of forepaws and hindpaws of ICOS+/+ and ICOS–/– mice 58 days after first immunization with chicken CII.