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. 1991 May;92:71–74. doi: 10.1289/ehp.92-1519395

Chromium-induced kidney disease.

R P Wedeen 1, L F Qian 1
PMCID: PMC1519395  PMID: 1935854

Abstract

Kidney disease is often cited as one of the adverse effects of chromium, yet chronic renal disease due to occupational or environmental exposure to chromium has not yet been reported. Occasional cases of acute tubular necrosis (ATN) following massive absorption of chromate have been described. Chromate-induced ATN has been extensively studied in experimental animals following parenteral administration of large doses of potassium chromate (hexavalent) (15 mg/kg body weight). The chromate is selectively accumulated in the convoluted proximal tubule where necrosis occurs. An adverse long-term effect of low-dose chromium exposure on the kidneys is suggested by reports of low molecular weight (LMW) proteinuria in chromium workers. Excessive urinary excretion of beta 2-microglobulin, a specific proximal tubule brush border protein, and retinol-binding protein has been reported among chrome platers and welders. However, LMW proteinuria occurs after a variety of physiologic stresses, is usually reversible, and cannot by itself be considered evidence of chronic renal disease. Chromate-induced ATN and LMW proteinuria in chromium workers, nevertheless, raise the possibility that low-level, long-term exposure may produce persistent renal injury. The absence of evidence of chromate-induced exposure may produce persistent renal injury. The absence of evidence of chromate-induced chronic renal disease cannot be interpreted as evidence of the absence of such injury. Rather, it must be recognized that no prospective cohort or case-control study of the delayed renal effects of low-level, long-term exposure to chromium has been published.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baines A. D. Cell renewal following dichromate induced renal tubular necrosis. An enzyme histochemical study. Am J Pathol. 1965 Nov;47(5):851–876. [PMC free article] [PubMed] [Google Scholar]
  2. Berndt W. O. Renal chromium accumulation and its relationship to chromium-induced nephrotoxicity. J Toxicol Environ Health. 1976 Jan;1(3):449–459. doi: 10.1080/15287397609529344. [DOI] [PubMed] [Google Scholar]
  3. Biber T. U., Mylle M., Baines A. D., Gottschalk C. W., Oliver J. R., MacDowell M. C. A study by micropuncture and microdissection of acute renal damage in rats. Am J Med. 1968 May;44(5):664–705. doi: 10.1016/0002-9343(68)90251-9. [DOI] [PubMed] [Google Scholar]
  4. Franchini I., Mutti A., Cavatorta A., Corradi A., Cosi A., Olivetti G., Borghetti A. Nephrotoxicity of chromium. Remarks on an experimental and epidemiological investigation. Contrib Nephrol. 1978;10:98–110. [PubMed] [Google Scholar]
  5. Franchini I., Mutti A. Selected toxicological aspects of chromium(VI) compounds. Sci Total Environ. 1988 Jun 1;71(3):379–387. doi: 10.1016/0048-9697(88)90210-0. [DOI] [PubMed] [Google Scholar]
  6. Kramp R. A., MacDowell M., Gottschalk C. W., Oliver J. R. A study by microdissection and micropuncture of the structure and the function of the kidneys and the nephrons of rats with chronic renal damage. Kidney Int. 1974 Feb;5(2):147–176. doi: 10.1038/ki.1974.19. [DOI] [PubMed] [Google Scholar]
  7. Laborda R., Díaz-Mayans J., Núez A. Nephrotoxic and hepatotoxic effects of chromium compounds in rats. Bull Environ Contam Toxicol. 1986 Mar;36(3):332–336. doi: 10.1007/BF01623516. [DOI] [PubMed] [Google Scholar]
  8. Lindberg E., Vesterberg O. Urinary excretion of chromium in chromeplaters after discontinued exposure. Am J Ind Med. 1989;16(5):485–492. doi: 10.1002/ajim.4700160502. [DOI] [PubMed] [Google Scholar]
  9. Lindberg E., Vesterberg O. Urinary excretion of proteins in chromeplaters, exchromeplaters and referents. Scand J Work Environ Health. 1983 Dec;9(6):505–510. doi: 10.5271/sjweh.2388. [DOI] [PubMed] [Google Scholar]
  10. Mathur A. K., Chandra S. V., Tandon S. K. Comparative toxicity of trivalent and hexavalent chromium to rabbits. II. Morphological changes in some organs. Toxicology. 1977 Aug;8(1):53–61. doi: 10.1016/0300-483x(77)90023-3. [DOI] [PubMed] [Google Scholar]
  11. McAughey J. J., Samuel A. M., Baxter P. J., Smith N. J. Biological monitoring of occupational exposure in the chromate pigment production industry. Sci Total Environ. 1988 Jun 1;71(3):317–322. doi: 10.1016/0048-9697(88)90203-3. [DOI] [PubMed] [Google Scholar]
  12. Rosansky S. J., Huntsberger T. L., Jackson K., Eggers P. Comparative incidence rates of end-stage renal disease treatment by state. Am J Nephrol. 1990;10(3):198–204. doi: 10.1159/000168081. [DOI] [PubMed] [Google Scholar]
  13. Sayato Y., Nakamuro K., Matsui S., Ando M. Metabolic fate of chromium compounds. I. Comparative behavior of chromium in rat administered with Na251CrO4 and 51CrCl3. J Pharmacobiodyn. 1980 Jan;3(1):17–23. doi: 10.1248/bpb1978.3.17. [DOI] [PubMed] [Google Scholar]
  14. Verschoor M. A., Bragt P. C., Herber R. F., Zielhuis R. L., Zwennis W. C. Renal function of chrome-plating workers and welders. Int Arch Occup Environ Health. 1988;60(1):67–70. doi: 10.1007/BF00409381. [DOI] [PubMed] [Google Scholar]
  15. Weber H. Long-term study of the distribution of soluble chromate-51 in the rat after a single intratracheal administration. J Toxicol Environ Health. 1983 Apr-Jun;11(4-6):749–764. doi: 10.1080/15287398309530382. [DOI] [PubMed] [Google Scholar]

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