FIG. 5.

Rolling (A) and adhesion (B) of leukocytes to brain endothelium of mice lacking P-selectin on day 6 of P. berghei malaria. We assessed the mean plus or minus SEM of leukocyte rolling and adherence by using intravital microscopy in five brain venules of four infected and four uninfected P-selectin-deficient mice. The rolling and adherence of leukocytes in C57BL/6 controls on day 0 and day 6 of infection in panels A and B are repeated from Fig. 4 for comparison. Shown is a statistically significant (P < 0.05) difference in leukocyte rolling or adhesion from that found in P-selectin-deficient mice (*) or C57BL/6 controls (#) on day 6 of P. berghei infection (A and B).