TABLE 1.
Results of experimental infections of C57BL/6 mice with H. pylori Hp141, Hp145, and SS1
| Infection model | Infecting strain(s) | Sacrifice interval (days) | No. of infected mice/no. tested | Colonization level (log CFU/stomach)a | ES profile |
|---|---|---|---|---|---|
| Single infection | Hp141 | 3 | 2/2 | 2-3.1 | Hp141 |
| 8 | 2/2 | 2.7-3.5 | Hp141 | ||
| 15 | 2/2 | 3.7-3.5 | Hp141 | ||
| 21 | 2/2 | 3.5-3.7 | Hp141 | ||
| 45 | 2/2 | 3.7-3.8 | Hp141 | ||
| 90 | 2/2 | 2.9-3.0 | Hp141 | ||
| 150 | 2/2 | 3.4-3.6 | Hp141 | ||
| 365 | 2/2 | 3.3-3.5 | Hp141 + Hp141v | ||
| Hp145 | 3 | 2/2 | 2.7-2.8 | Hp145 | |
| 8 | 2/2 | 2.8-3 | Hp145 | ||
| 15 | 2/2 | 3.1-3.4 | Hp145 | ||
| 21 | 2/2 | 3.6-3.7 | Hp145 | ||
| 45 | 2/2 | 3.6-3.8 | Hp145 | ||
| 90 | 2/2 | 3.5-3.8 | Hp145 | ||
| 150 | 2/2 | 3.1-3.3 | Hp145 | ||
| 365 | 2/2 | 3-3.5 | Hp145 | ||
| SS1 | 3 | 2/2 | 6-8.3 | SS1 | |
| 8 | 2/2 | 7.4-8 | SS1 | ||
| 15 | 2/2 | 6.1-8.3 | SS1 | ||
| 21 | 3/3 | 5.2-5.4-5.7 | SS1 | ||
| 45 | 3/3 | 4.3-4.5-4.6 | SS1 | ||
| 90 | 3/3 | 3.1-4.8-5.2 | SS1 | ||
| 150 | 2/2 | 2.3-3.8 | SS1 | ||
| 365 | 2/2 | 3.2-3.4 | SS1 | ||
| Coinfection | Hp141 + SS1 | 45 | 1/2 | 2.3 | SS1 |
| Hp145 + SS1 | 45 | 1/2 | 2.3 | SS1 | |
| Hp141 + Hp145 | 45 | 3/4 | 2.8-2.8-3.5 | Hp141 | |
| Hp141 + Hp145 + SS1 | 45 | 2/2 | 2.5 | Hp141v | |
| 2.3 | SS1 | ||||
| Superinfection | Hp141 and then Hp145 | 90 | 3/4 | 3.5-3.6-3.7 | Hp141 |
| Hp145 and then Hp141 | 90 | 2/3 | 1.6 | Hp145 | |
| 1.3 | Hp141 | ||||
| No infection (negative controls)b | None | 0/30 | 0 |
a
Values obtained for each infected mouse.
b
Three control mice were sacrificed at each interval.