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Time courses of allodynia induced by PGE2, PGF2α, and bicuculline in wild-type and L-PGDS−/− mice. PGE2 (10 ng, A), PGF2α (1 μg, B), or bicuculline (25 ng, C) was injected into the subarachnoid space of wild-type (○, ▵, □) and L-PGDS−/− mice (•, ▴, ■) mice. Assessment of allodynia was made as described in Materials and Methods. The value (mean ± SEM) represents the percent of the maximum possible cumulative score of 5–6 mice evaluated every 5 min.
