Table 1.
Allodynia induced by various agents in wild-type and L-PGDS−/−mice
| Agent | Allodynia, %
|
|
|---|---|---|
| +/+ | −/− | |
| PGD2, 100 ng | 0.0 | 0.0 |
| PGE2, 10 ng | 67.5 ± 7.7 | 0.0* |
| PGF2α, 1 μg | 85.0 ± 8.9 | 87.5 ± 8.1 |
| Bicuculline, 25 ng | 76.7 ± 8.4 | 6.7 ± 4.0* |
| Strychnine, 250 ng | 79.0 ± 9.8 | 75.0 ± 8.9 |
| AMPA, 10 ng | 81.0 ± 10.1 | 78.3 ± 8.7 |
| NMDA, 10 ng | 74.0 ± 8.7 | 65.8 ± 8.2 |
| Arginine, 5 μg | 80.0 ± 9.9 | 74.2 ± 9.1 |
| SNP, 10 ng | 73.8 ± 11.4 | 75.8 ± 9.4 |
Data (mean ± SEM, n = 5–6) are expressed as a percent of the maximum possible cumulative score over the 50-min experiment. ∗, P < 0.01 compared to wild-type (+/+) mice. AMPA, α-amino-3-hydroxy-5-methyl-4-isoxalole-4-propionic acid; NMDA, N-methyl-d-aspartate; SNP, sodium nitroprusside.