TABLE 2.
Human monocyte genes that are pneumolysin dependent and differentially expressed in response to S. pneumoniaea
| Function group and accession no. | Locus | Gene name | Molecular function | Change in expression (fold) with exposure to:
|
|
|---|---|---|---|---|---|
| D39 vs. medium | D39 vs. PLN | ||||
| Antipathogen response | |||||
| T72877 | IL1RN | Interleukin 1 receptor antagonist | 1.3 | 3.5 | |
| AA446103 | LMAN1 | Lectin, mannose-binding, 1 | Chaperone; mannose-binding lectin | 2.4 | 3.3 |
| N63943 | LYZ | Lysozyme (renal amyloidosis) | Lysozyme; amyloid protein; lysine | 3.0 | 2.9 |
| AA521362 | CR2/CD21 | Complement component receptor 2 | 1.2 | 0.3 | |
| Cell adhesion | |||||
| T65118 | CTNNA1 | Catenin alpha 1 | Cadherin-associated protein | 16.0 | 14.2 |
| AA088861 | CDH17 | Cadherin 17 | Calcium-dependent cell adhesion | 2.0 | 2.1 |
| Cell cycle control: AA448659 | CDC25B | Cell division cycle 25B | Protein tyrosine phosphatase | 5.7 | 3.7 |
| Cell death and apoptosis | |||||
| H44953 | CASP4 | Caspase 4 | Apoptosis-related Cys protease | 3.1 | 2.6 |
| W45688 | CASP6 | Caspase 6 | Apoptosis-related Cys protease | 3.2 | 2.2 |
| Cell-to-cell signaling | |||||
| H62864 | SCYA4 | Small inducible cytokine A4 (MIP-1β) | Protein kinase; chemokine | 5.9 | 4.9 |
| AA040170 | SCYA7 | Small inducible cytokine A7 (MCP3) | Chemokine | 3.9 | 3.1 |
| AA102526 | IL8 | Interleukin 8 | Cytokine | 2.7 | 2.4 |
| Lipid, fatty-acid, and sterol metabolism | |||||
| AA436163 | PTGES | Prostaglandin E synthase | Antimicrobial humoral response | 4.0 | 3.9 |
| AA464238 | PAFAH1B3 | Platelet-activating factor acetylhydrolase | Lipid metabolism; neurogenesis | 0.9 | 0.4 |
| Protein degradation: H94487 | CTSE | Cathepsin E | Proteolysis and peptidolysis | 3.5 | 2.1 |
| Protein folding | |||||
| R98019 | APCS | Amyloid P component, serum | Acute-phase response protein | 1.5 | 4.0 |
| AA676404 | PPIC | Cyclophilin C | Peptidylprolyl isomerase | 4.8 | 3.1 |
| Protein translocation: AA682386 | OLR1 | Oxidized low-density lipoprotein receptor 1 | LDL receptor | 0.93 | 0.14 |
| Signal transduction | |||||
| AA057204 | IL2RB | Interleukin 2 receptor, beta | Signal transduction | 2.2 | 5.2 |
| AA054754 | IL15RA | Interleukin 15 receptor, alpha | Signal transduction | 2.3 | 4.5 |
| AA485426 | IFNAR2 | Interferon (α, β, and ο) receptor 2 | Antiviral response protein | 3.5 | 2.2 |
| AA431967 | TXN | Thioredoxin | Antimicrobial humoral response | 2.3 | 2.1 |
a
Data from all arrays used in this study are available at http://dcp.utmem.edu/drogers/.