TABLE 4.
GMTs and 95% CIs for SBA titers and the percentage of vaccine responders after vaccination against patient isolates of the same subtype as the vaccine strains with subtype P1.5-1,2-2 and P1.5-2,10
| Strain | GMT (95% CI) | % of children with 4-fold increase in titer |
|---|---|---|
| P1.5-1,2-2 | ||
| Isogenic H44/76 | 53.2 (35.8-79.1) | 97.8 |
| 126E | 37.0 (24.1-56.5) | 95.6 |
| 5372 | 20.8b (13.7-31.7) | 95.6 |
| P1.5-2,10 | ||
| Isogenic H44/76 | 383.0 (288.3-508.6) | 100 |
| B40 | 29.7b (21.8-40.5) | 100 |
| 21/51 | 70.3b (52.7-93.7) | 100 |
| 870227 | 25.8b (19.4-34.2) | 100 |
a
All data are from trial I post booster (n = 46).
b
Significantly higher or lower than GMT against the vaccinee strain in SBA (Wilcoxon signed rank test).