FIG. 7.

Hematoxylin and eosin-stained colonic frozen sections from C3H/Hej mice experimentally infected with C. rodentium. (A) Colonic sections from an uninfected mouse, showing normal colonic architecture. (B) Crypt hyperplasia and inflammation in a mouse infected with wild-type C. rodentium. (C) Infection with cesD2-minus derivative (ICC173), similarly to the uninfected control, revealed neither hyperplasia nor inflammatory response. (D and E) Complementation of ICC173 with pICC245 (D) or pICC246 (E) restored both hyperplastic and inflammatory responses. Original magnification, ×200.