Localization of orexin-A and -B from rostal (A) to caudal (S) in rat brain. Orexin neurons: large filled circles. Orexin nerve fibers: small dots. 3, oculomotor nucleus; 10, dorsal motor nucleus of vagus; ac, anterior commissure; aca, anterior commissure, anterior part; AOB, accessory olfactory bulb; AP, area postrema; Aq, aqueduct; Arc, arcuate hypothalamic nucleus; CA1–3, fields CA1–3 of hippocampus; CG, central gray; CPu, caudate putamen; DMD, dorsomedial hypothalamic nucleus, dorsal part; DR, dorsal raphe nucleus; f, fornix; GI, granular insular cortex; Gl, glomerular layer of the olfactory bulb; GrA, granule cell layer of the accessory olfactory bulb; IL, infralimbic cortex; LA, lateroanterior hypothalamic nucleus; LC, locus coeruleus; LH, lateral hypothalamus; lo, lateral olfactory tract; LPGi, lateral paragigantocellular nucleus; LSD, lateral septal nucleus, dorsal part; LSI, lateral septal nucleus, intermediate part; M1, primary motor cortex; ME, median eminence; Mi, mitral cell layer of the olfactory bulb; ml, medial lemniscus; mt, mammillothalamic tract; NTS, nucleus of the solitary tract; ON, olfactory nerve layer; opt, optic tract; ox, optic chiasm; PH, posterior hypothalamus; Pir, piriform cortex; PRh, perirhinal cortex; PrH, prepositus hypoglossal nucleus; PrL, prelimbic cortex; PVN, paraventricular hypothalamic nucleus; PVT, paraventricular thalamic nucleus; S1, primary somatosensory cortex; SCN, suprachiasmatic nucleus; SNC, substantia nigra, compact part; SON, supraoptic nucleus; Sp5, spinal trigeminal nucleus; SuM, supramammillary nucleus; VMH, ventromedial hypothalamic nucleus.