TABLE 1.
Proportions of Gambian children acquiring clinical malaria in July to November in groups with or without serum IgG to different parts of MSP1 block 2 in June
| MSP1 recombinant antigen | % Acquiring clinical malariaa
|
Relative risk (95% confidence interval) | Univariate P value | Age-corrected P value | |
|---|---|---|---|---|---|
| IgG-positive individuals | IgG-negative individuals | ||||
| K1-like block 2 | |||||
| Flanking nonrepeats | 46.9 (15/32) | 55.0 (166/302) | 0.85 (0.58-1.25) | 0.38 | 0.55 |
| Palo Alto repeats | 27.3 (9/33) | 57.1 (172/301) | 0.48 (0.27-0.84) | 0.001 | 0.014 |
| 3D7 repeats | 32.4 (11/34) | 56.7 (170/300) | 0.57 (0.35-0.94) | 0.007 | 0.047 |
| MAD-like block 2 | |||||
| Flanking nonrepeats | 56.8 (42/74) | 53.5 (139/260) | 1.06 (0.84-1.33) | 0.62 | 0.36 |
| Wellcome repeats | 32.5 (13/40) | 57.1 (168/294) | 0.57 (0.36-0.90) | 0.003 | 0.012 |
| MAD20 repeats | 41.3 (19/46) | 56.3 (162/288) | 0.73 (0.51-1.05) | 0.059 | 0.192 |
a
A total of 334 children were studied. The values in parentheses are number who acquired clinical malaria/total numbers who were IgG positive or IgG negative for the given antigen.